Overview:

The Cardiac Troponin I - interacting kinase (TNNI3K) is a serine/threonine-protein kinase, that is a member of the MAPKKK family (1). As a cardiac-specific kinase, it contains Ankyrin repeat, protein kinase, and serine-rich domains and highly expressed in the cardiomyocytes (1). Overexpression of TNNI3K has been shown to increase the progression of cardiomyopathy in mice through the Tyr and Ser/Thr kinase activity (2). The TNNI3K mutation has been involved in a familial syndrome of conduction system disease and dilated cardiomyopathy by causing the aggregation of this protein (3).

Gene Aliases:

CARK, CCDD

Genbank Number:

BC117262

References:

1. Y. Zhao, et al: Cloning and characterization of a novel cardiac-specific kinase that interacts specifically with cardiac troponin I. J Mol Med. 81: 297–304, 2003.

2. H. Tang, et al: Overexpression of TNNI3K, a cardiac specific MAPKKK, promotes cardiac dysfunction. J Mol Cell Cardiol. 54: 101-111, 2013.

3. J. L. Theis, et al: TNNI3K mutation in familial syndrome of conduction system disease, atrial tachyarrhythmia and dilated cardiomyopathy. Human Molecular Genetics. 23: 5793-5804, 2014.