Full-length recombinant human FYN A was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. F15-10G
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| F15-10G-05 | 5 ug | $226 | |
| F15-10G-10 | 10 ug | $325 | |
| F15-10G-BULK | BULK | Contact Us |
Overview:
Fyn A (Fyn isoform A) is a member of the SRC tyrosine kinase oncogene family showing high homology to YES1, FGR and SRC. Fyn has been shown to phosphorylate Dab1, an intracellular adaptor protein that interacts with amyloid precursor protein (APP) and apoE receptor 2 (apoEr2) (1). The interaction of Fyn and Dab1 regulates the phosphorylation, trafficking, and processing of APP and apoEr2. Fyn expression has been shown to be significantly increased in Chronic Myelogenous Leukemia (CML) (2). Knockdown of Fyn with shRNA slows leukemia cell growth, inhibits clonogenicity, and leads to increased sensitivity to imatinib.
Gene Aliases:
SLK, SYN, MGC45350
Genbank Number:
References:
1. Hoe, H S. et al: Fyn modulation of Dab1 effects on amyloid precursor protein and ApoE receptor 2 processing. J. Biol. Chem. 2008 Mar 7;283(10):6288-99.
2. Ban, K. et al: BCR-ABL1 mediates up-regulation of Fyn in chronic myelogenous leukemia. Blood, 2008 Mar 1;111(5):2904-8.
Specific Activity:
Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
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Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
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Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
~85kDa
Ruilong L et al., Tyrosine phosphorylation activates 6-phosphogluconate dehydrogenase and promotes tumor growth and radiation resistance
Nature Communications March 2019 10.1038/s41467-019-08921-8
A Binolfi et al., Intracellular repair of oxidation-damaged [alpha]-synuclein fails to target C-terminal modification sites Nature Communications January 2016 10.1038/ncomms10251
Y Yamazaki et al., Nicotine-induced neuroplasticity counteracts the effect of schizophrenia-linked neuregulin 1 signaling on NMDAR function in the rat hippocampus Neuropharmacology October 2016 10.1016/j.neuropharm.2016.10.021
Y Yamazaki et al., Nicotine-induced neuroplasticity counteracts the effect of schizophrenia-linked neuregulin 1 signaling on NMDAR function in the rat hippocampus. Neuropharmacology October 2016 10.1016/j.neuropharm.2016.10.021
et al., Dual role of the RNA helicase DDX5 in post-transcriptional regulation of myelin basic protein in oligodendrocytes. Journal of cell science December 2019
et al., Computational-experimental approach to drug-target interaction mapping: A case study on kinase inhibitors PLoS Computational Biology August 2017
Cancer, Cardiovascular Disease, Cytoplasmic Tyrosine Kinases, ERK/MAPK Pathway, Inflammation, Invasion/Metastasis, Neurobiology
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