Recombinant full-length human DMPK was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. D07-10G
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
D07-10G-05 | 5 ug | $226 | |
D07-10G-10 | 10 ug | $325 | |
D07-10G-BULK | BULK | Contact Us |
Overview:
DMPK (or Myotonic Dystrophy Protein Kinase) is a serine-threonine kinase that is closely related to other kinases that interact with members of the Rho family of small GTPases. DMPK protein has a leucine-rich domain at the N-terminus, a serine/threonine kinase domain in the middle, and a hydrophobic region at the C-terminus. The N-terminus of DMPK plays an important role in DMPK kinase activity, and the C-terminus of DMPK determines the intracellular localization of the protein (1). Myotonic dystrophy type 1 is an autosomal dominant disease caused by a trinucleotide repeat-expansion, cytosine-thymine-guanine (CTG)n, in the 3' untranslated region of DMPK (2).
Gene Aliases:
DM, DM1, DMK, MDPK, DM1PK, MT-PK
Genbank Number:
References:
1. Sasagawa, N. et al: Overexpression of human myotonic dystrophy protein kinase in Schizosaccharomyces pombe induces an abnormal polarized and swollen cell morphology. J Biochem. 2003 Oct;134(4):537-42.
2. Salvatori, S. et al: Decreased expression of DMPK: correlation with CTG repeat expansion and fibre type composition in myotonic dystrophy type 1. Neurol Sci. 2005 Oct;26(4):235-42.
Specific Activity:
Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
~105kDa
There are no related publications available for this product.
Cancer, Cardiovascular Disease, Ser/Thr Kinases
STAY CONNECTED
Fax: 1-604-232-4601