Recombinant human CDK13 (516-end) /Cyclin K complex was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag on both proteins.
Catalog No. C25-11BG
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| C25-11BG-05 | 5 ug | $259 | |
| C25-11BG-10 | 10 ug | $380 | |
| C25-11BG-BULK | BULK | Contact Us |
Overview:
CDK13 or cyclin-dependent kinase 13 is a member of the cyclin-dependent serine/threonine protein kinase family which are well known for their essential roles as master switches in cell cycle control. CDK13 forms a complex with cyclin K and is predicted to play a role in gene regulation (1). CDK13 may play a role in mRNA processing and is thought to be involved in regulation of hematopoiesis (2). The CYCK-CDK12 and CYCK-CDK13 complexes display unique function in cell cycle and gene regulation.
Gene Aliases:
CDK13: CDC2L; CDC2L5; CHED; hCDK13 CyclinK: CCNK, CPR4, MGC9113
References:
1. Blazek, D.et.al: The cyclin K/Cdk12 complex maintains genomic stability via regulation of expression of DNA damage response genes. Genes Dev. 25: 2158-2172, 2011. 2. Lapidot-Lifson, Y.et.al: Cloning and antisense oligodeoxynucleotide inhibition of a human homolog of cdc2 required in hematopoiesis. Proc. Nat. Acad. Sci. 89: 579-583, 1992.
Specific Activity:
Sample Enzyme Activity Plot. For specific information on a given lot, see related technical data sheet.
|
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
|
Storage and Stability:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular weight:
CDK13 approx. MW 160kDa and CyclinK Approx. MW 67kDa.
There are no related publications available for this product.
Cancer, Cell Cycle, Ser/Thr Kinases
STAY CONNECTED
Fax: 1-604-232-4601
Toll Free: 1-866-954-6273
info@signalchem.com