Recombinant human DTYMK (2-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. D31-11G
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
D31-11G-05 | 05 ug | $226 | |
D31-11G-10 | 10 ug | $325 | |
D31-11G-BULK | BULK | Contact Us |
Overview:
DTYMK belongs to a family of thymidylate kinase proteins (1). DTYMK catalyzes phosphorylation of deoxy-TMP to the corresponding phosphate in the presence of ATP and magnesium. This enzyme is essential for cellular DNA synthesis and is an important intermediate enzyme in the pathway of many pyrimidine analog drugs (2). Elevated levels of dTMP have been correlated with poor survival in lung adenocarcinomas hence it is a potential anticancer therapeutic target (3).
Gene Aliases:
CDC8, PP3731, TMPK, TYMK, deoxythymidylate kinase
Genbank Number:
References:
1. Su, J.Y. et al: Molecular cloning and expression of the human deoxythymidylate kinase gene in yeast. Nucleic Acids Res. 1991; 19(4): 823–827.
2. Huang, S. et al: Human dTMP Kinase: Gene expression and enzymatic activity coinciding with cell cycle progression and cell growth. DNA and Cell Biology. 1994; 13(5):461-471.
3. Liu, Y. et al: Metabolic and functional genomic studies identify deoxythymidylate kinase as a target in LKB1-mutant lung cancer. Cancer Discov. 2013; 3(8):870-879.
Specific Activity :
Sample activity data. For lot specific data please refer to the specific lot datasheet.
Purity:
sample purity data. For lot-specific data please refer to the lot-specific datasheet.
Storage, Stability, and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
Approx. MW 50 kDa.
There are no related publications available for this product.
Angiogenesis, Apoptosis/Autophagy, Cancer, Cardiovascular Disease, Cell Cycle, Cellular Stress, Inflammation, Metabolic Disorder, Neurobiology
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