JAK3 is a member of the JAK family of tyrosine kinases involved in cytokine receptor-mediated intracellular signal transduction. Low levels of JAK3 expression is detected in immature hematopoietic cells, which dramatically increases during terminal differentiation of these cells suggesting a role of JAK3 in the differentiation of hematopoietic cells. Mutations in JAK3 are associated with autosomal SCID (severe combined immunodeficiency disease) (1). Mice lacking JAK3 show a severe block in B-cell development at the pre-B stage in bone marrow suggesting that JAK3 is critical for the progression of B-cell development in the bone marrow (2).
JAKL, LJAK, JAK-3, L-JAK, JAK3_HUMAN
1.Russell S M, et al: Mutation of Jak3 in a patient with SCID: essential role of Jak3 in lymphoid development. Science 270: 797-799, 1995.
2.Thomis D C, et al: Defects in B lymphocyte maturation and T lymphocyte activation in mice lacking Jak3. Science 270: 794-797, 1995.
Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
E. Elliott Natalina et al., FERM domain mutations induce gain of function in JAK3 in adult T-cell leukemia/lymphoma Blood July 2011 10.1182/blood-2010-12-319467
Scuto A et al., The novel JAK inhibitor AZD1480 blocks STAT3 and FGFR3 signaling, resulting in suppression of human myeloma cell growth and survival Leukemia March 2011 10.1038/leu.2010.289
Kosten Jonas et al., Efficient Modification of Alpha-Synuclein Serine 129 by Protein Kinase CK1 Requires Phosphorylation of Tyrosine 125 as a Priming Event ACS Chemical Neuroscience October 2014 10.1021/cn5002254
Cancer, Cardiovascular Disease, Cytoplasmic Tyrosine Kinases, Inflammation, JAK/STAT Pathway