Overview:

CDK11 is a member of the cyclin-dependent kinase 11 family which is known to be essential for eukaryotic cell cycle control and it is in close proximity to CDC2L2, a nearly identical gene in the same chromosomal region. CDK11 is a negative regulator of normal cell cycle progression and Its expression is regulated during murine embryogenesis, and its activity is coordinately regulated with that of p34 (cdc2) during the cell cycle (1). CDK11 gene may harbor 1 or more tumor suppressor genes that affected by chromosome 1p36 modifications in neuroblastoma (2). CDK11 could be cleaved by caspases and was demonstrated to play roles in cell apoptosis.

Gene Aliases:

CDK19; CDC2L6; CDK8-like; bA346C16.3; KIAA1028

Genbank Number:

NM_015076

References:

1. Bunnell, B. et.al: Elevated expression of a p58 protein kinase leads to changes in the CHO cell cycle. Proc. Nat. Acad. Sci. 87: 7467-7471, 1990.

2. Lahti, J. M. et.al: Alterations in the PITSLRE protein kinase gene complex on chromosome 1p36 in childhood neuroblastoma. Nature Genet. 7: 370-375, 1994.