Recombinant full-length human p38beta was expressed in E. coli cells using an N-terminal GST tag.
Catalog No. M36-14G
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
M36-14G-20 | 20 ug | $215 | |
M36-14G-50 | 50 ug | $435 | |
M36-14G-BULK | BULK | Contact Us |
Overview:
p38-β is a member of the p38 MAP kinase family and is activated by both proinflammatory cytokines and environmental stress (1). The p38-beta is activated through its phosphorylation by MAP kinase kinases (MKKs), preferably by MKK6. Transcription factor ATF2/CREB2 has been shown to be a substrate of this kinase (2). Alternatively spliced transcript variants encoding the same protein have been observed.
Gene Aliases:
MAPK11; SAPK2; p38-2; PRKM11; SAPK2B; p38b; P38b2
Genbank Number:
References:
1. Jiang, Y. et al: Characterization of the structure and function of a new mitogen-activated protein kinase (p38-beta). J. Biol. Chem. 271: 17920-17926, 1996.
2. Stein, B. et al: p38-2, a novel mitogen-activated protein kinase with distinct properties. J. Biol. Chem. 272: 19509-19517, 1997.
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles
Molecular Weight:
~69 kDa
Angiogenesis, Apoptosis/Autophagy, Cardiovascular Disease, Cellular Stress, Inflammation, Metabolic Disorder, Neurobiology, NfkB Pathway, p38 Pathway, Ser/Thr Kinases
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