Recombinant full-length human AURORA C was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. A33-14G
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| A33-14G-20 | 20 ug | $215 | |
| A33-14G-50 | 50 ug | $435 | |
| A33-14G-BULK | BULK | Contact Us |
Overview:
AURORA C is a member of mitotic serine/threonine kinases that regulate centrosome maturation, chromosome segregation, and cytokinesis. AURORA C has been shown to contribute to oncogenic transformation and is frequently overexpressed and amplified in many human tumors (1). AURORA C overexpression has been correlated with centrosome amplification, which can be a driving cause of genomic instability in tumor cells. AURORA C is an important regulator of both genomic integrity and cell cycle progression in cancer cells and is an attractive target for anticancer drug development (2).
Gene Aliases:
AURKC, AIE2, AIK3, AurC, STK13, aurora-C
Genbank Number:
References:
1. Steven, L. et al: Targeting Aurora-2 Kinase in Cancer. Molecular Cancer Therapeutics. 2003;2: 589-595.
2. Shingo, T. et al: The centrosomal protein Lats2 is a phosphorylation target of Aurora-A kinase. Genes to Cells. 2004; 9: 383-397.
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
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Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
~61 kDa
Cancer, Cell Cycle, Ser/Thr Kinases
AURORA A, Unactive, A28-14G
AURORA B, Unactive, A31-14G
AURORA A, Active, A28-10G
AURORA A, Active, A28-18G
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