Overview:

STK36 is a member of the serine/threonine kinase family and is similar to a protein which plays a key role in the Hedgehog signaling pathway. STK36 is a positive regulator of the GLI zinc-finger transcription factors and controls the activity of GLI1 and GLI2 by opposing the effect of SUFU (1). STK36 is highly expressed in fetal lung and adult testis (2). STK36 is a target for the treatment of gastrointestinal cancers since the Hedgehog signaling pathway is frequently activated in certain kinds of gastrointestinal cancers. Defects in the STK36 gene may lead to congenital hydrocephalus, possibly due to a functional defect in motile cilia.

Gene Aliases:

FU, DKFZp434N0223

Genbank Number:

BC026158

References:

1. Murone, M. et.al: Gli regulation by the opposing activities of Fused and Suppressor of Fused. Nature Cell Biol. 2: 310-3112, 2000.

2. Nagase, T. et.al: Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. DNA Res. 6: 337-345, 1999.