Full-length recombinant human PCTK3 (CDK18) and Cyclin Y (2-end) were co-expressed by baculovirus in Sf9 insect cells using N-terminal GST tags.
Catalog No. P11-10G
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| P11-10G-05 | 5 ug | $259 | |
| P11-10G-10 | 10 ug | $380 | |
| P11-10G-BULK | BULK | Contact Us |
Overview:
PCTK3 or PCTAIRE protein kinase 3 is a member of the cdc2/cdkx subfamily of the ser/thr family of protein kinases. PCTK3 is thought to play a role in terminally differentiated neurons and it contains an N-terminal extension relative to CDC2 (1). PCTK3 is expressed in a variety of human cell lines and tissues (2). Elevation in the protein levels of PCTAIRE 3 in the temporal cortex of Alzheimer's disease relative to control brains, have been observed. It is proposed that PCTAIRE 3 is a paired helical filaments-associated kinase that modulates tau phosphorylation.
Gene Aliases:
PCTK3: PCTAIRE, PCTAIRE3 CyclinY: CCNY; C10orf9; CBCP1; CCNX; CFP1
References:
1. Meyerson, M.et.al: A family of human cdc2-related protein kinases. EMBO J. 11: 2909-2917, 1992.
2. Okuda, T.et.al: PCTAIRE-1 and PCTAIRE-3, two members of a novel cdc2/CDC28-related protein kinase gene family. Oncogene 7: 2249-2258, 1992
Specific Activity:
Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
|
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
|
Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
PCTK3 (CDK18) ~76 kDa and Cyclin Y ~65 kDa
M Kanke et al., Cohesin acetylation and Wapl-Pds5 oppositely regulate translocation of cohesin along DNA. EMBO Journal November 2016 10.15252/embj.201695756
Bhandaria Deepali et al., Cyclin-dependent kinase 5 activates guanine nucleotide exchange factor GIV/Girdin to orchestrate migration?proliferation dichotomy PNAS July 2015 10.1073/pnas.1514157112
et al., Discovery of covalent CDK14 inhibitors with pan-TAIRE family specificity Cell chemical biology June 2020
Cancer, Cell Cycle, Ser/Thr Kinases
Kinase Dilution Buffer III, K23-09
Kinase Assay Buffer I, K01-09
MBP Protein, M42-51N
PCTK2 Protein, P10-34G
STAY CONNECTED
Fax: 1-604-232-4601
Toll Free: 1-866-954-6273
info@signalchem.com