Recombinant full-length human TRIB3 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. T32-30G
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| T32-30G-20 | 20 ug | $215 | |
| T32-30G-50 | 50 ug | $435 | |
| T32-30G-BULK | BULK | Contact Us |
Overview:
TRIB3 or tribbles homolog 3 protein encode one of three members of the Tribbles family that share a Trb domain, which is homologous to protein serine-threonine kinases, but lacks the active site lysine and probably lacks a catalytic function. TRIB3 is a negative regulator of NF-kappaB and can also sensitize cells to TNF- and TRAIL-induced apoptosis. TRIB3 can negatively regulate the cell survival serine-threonine kinase AKT1. TRIB3 modulation by H. pylori and/or its products may be an important mechanism of H. pylori-associated pathogenesis (1). TRIB3 is a p65-interacting negative regulator of NF-kappa-B-dependent transcription (2). TRIB3 is highly expressed in pancreas, peripheral blood leukocytes, and bone marrow.
Gene Aliases:
NIPK, SINK, SKIP3, TRB3
Genbank Number:
References:
1. Qi, L.et.al: TRB3 links the E3 ubiquitin ligase COP1 to lipid metabolism. Science 312: 1763-1766, 2006.
2. Wu, M. et.al: SINK is a p65-interacting negative regulator of NF-kappa-B-dependent transcription. J. Biol. Chem. 278: 27072-27079, 2003.
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
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Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
~69 kDa
There are no related publications available for this product.
Cancer, Metabolic Disorder
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