Overview:

TXK or RLK is a member of the TEC family of non-receptor tyrosine kinases. TXK is expressed in T-cells and is an important component of signaling pathways downstream of lymphocyte antigen receptor. TXK is phosphorylated in response to T-cell receptor stimulation and can be activated by phosphorylation by Src family kinases. However, TXK is phosphorylated independent of PI-3K activity (1). Excessive TXK protein expression is seen in patients with Behcet's disease. Over production of TXK leads to increased Th1 cell function that is involved in the pathogenesis of Behcet’s disease (2).

Gene Aliases:

RLK; TKL; BTKL; PTK4; PSCTK5; MGC22473

Genbank Number:

NM_003328

References:

1. Czar, M J. et al: Biochemical and genetic analyses of the Tec kinases Itk and Rlk/Txk. Biochem Soc Trans. 2001Nov;29(Pt 6):863-7.

2. Suzuki, N. et al: Skewed Th1 responses caused by excessive expression of Txk, a member of the Tec family of tyrosine kinases, in patients with Behcet's disease. Clin Med Res. 2006 Jun;4(2):147-51.