Rabbit Polyclonal Antibody
Catalog No. D14-63R
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
D14-63R-100 | 100 ug | $595 | |
D14-63R-BULK | BULK | Contact Us |
Overview:
DCAMKL1 or doublecortin-like kinase 1 contains two N-terminal doublecortin domains (which bind microtubules and regulate microtubule polymerization), a C-terminal serine/threonine protein kinase domain (which shows substantial homology to Ca2+/calmodulin-dependent protein kinase), and a serine/proline-rich domain in between the doublecortin and the protein kinase domains (which mediates multiple protein-protein interactions) (1). DCAMKL1 is a microtubule-associated kinase that can undergo autophosphorylation. DCAMKL1 has microtubule-polymerizing activity that is independent of its protein kinase activity (2). DCAMKL1 is involved in several different cellular processes, including neuronal migration, retrograde transport, neuronal apoptosis and neurogenesis.
References:
1. Ohmae, S. et.al: Molecular identification and characterization of a family of kinases with homology to Ca(2+)/calmodulin-dependent protein kinases I/IV. J. Biol. Chem. 281: 20427-20439, 2006
2. Lin, P. T. et,al: DCAMKL1 encodes a protein kinase with homology to doublecortin that regulates microtubule polymerization. J. Neurosci. 20: 9152-9161, 2000.
Specificity:
Recognizes the DCAMKL1 protein
Cross Reactivity:
Human, Mouse and Rat
Host / Isotype / Clone#:
Rabbit, IgG
Immunogen:
DCAMKL1 antibody was raised against a 14 amino acid synthetic peptide near the amino terminus of human DCAMKL1
Purification:
Affinity chromatography
Stability:
Store at 4oC for up to one year. Antibodies should not be exposed to prolonged high temperatures.
Sample Data:
Western blot analysis of DCAMKL1 in human brain tissue lysate with DCAMKL1 antibody at (A) 0.5 and (B) 1 ug/ml.
Sample Data:
Immunohistochemistry of DCAMKL1 in rat brain tissue with DCAMKL1 antibody at 2.5 ug/ml.
There are no related publications available for this product.
Cardiovascular Disease, Neurobiology, PKA/PKC Pathway, Ser/Thr Kinases
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