Overview:

UBE2G1 (UBC7) or ubiquitin-conjugating enzyme E2G 1 is a member of the E2 ubiquitin-conjugating enzyme family and catalyzes the covalent attachment of ubiquitin to other proteins which are involved in degradation of muscle-specific proteins. UBC7 is highly expressed in skeletal muscle. UBC7 is involved in the selective ubiquitylation of different substrates by the same E3 complex.

Gene Aliases:

UBC7; E217K; UBE2G

Genbank Number:

NM_003342

References:

1. Mondal, S. et al: A bioluminescent assay for monitoring conjugation of ubiquitin and ubiquitin-like proteins. Anal. Biochem. 510: 41-51, 2016

2. Watanabe, T.K. et al: Molecular cloning of UBE2G, encoding a human skeletal muscle-specific ubiquitin-conjugating enzyme homologous to UBC7 of C. elegans. Cytogenet. Cell Genet. 74: 146-148, 1996

3. David, Y. et al: The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines. Cytogenet. J Biol Chem. 285(12): 8595-8604, 2010