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PTPN2 (TC-PTP), Active

Recombinant full length human PTPN2 was expressed in E. coli cells using a N-terminal GST tag.
Catalog No. P29-20G


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Catalog No. Pack Size Price (USD)
P29-20G-05 5 ug $160
P29-20G-10 10 ug $226
P29-20G-BULK BULK Contact Us  


Overview:

Protein tyrosine phosphatase, non-receptor type 2 (PTPN2), is one of the most abundant mammalian tyrosine phosphatase. The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family (1). By virtue of protein tyrosine phosphatase activity, PTPN2 is known to be a signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation involved in cell communication and signal transduction (2).


Gene Aliases:

TC-PTP, PTPT, TCELLPTP, TCPTP


Genbank Number:


References:


1. Gupta, S. et al: A nuclear protein tyrosine phosphatase activates p53 and induces caspase-1-dependent apoptosis. FEBS Lett. 2002; 532(1-2):61-6.

2. Yamamoto, T. et al: The nuclear isoform of protein-tyrosine phosphatase TC-PTP regulates interleukin-6-mediated signaling pathway through STAT3 dephosphorylation. Biochem. Biophys. Res. Commun.


Specific Activity:

Sample Enzyme Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~69 kDa



Product Datasheets



Safety Datasheet



RESEARCH AREAS

Cancer, Inflammation, Invasion/Metastasis, JAK/STAT Pathway, Metabolic Disorder, Phosphatases, WNT Signaling


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  PTPRM (PTP- mu) Protein, P58-35G


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