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PTPN12 (PTP-PEST), Active

Recombinant human PTPN12 (1-355) was expressed in E. coli cells using a N-terminal GST tag.
Catalog No. P39-21G


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Catalog No. Pack Size Price (USD)
P39-21G-05 5 ug $160
P39-21G-10 10 ug $226
P39-21G-BULK BULK Contact Us  


Overview:

Protein tyrosine phosphatase-PEST (PTPN12), a ubiquitously expressed cytoplasmic tyrosine phosphatase, is thought to play an important role in cell adhesion and motility, cell migration, and signal transduction for antigen receptors in B and T lymphocytes (1). Signal transduction via tyrosine phosphorylation, normally fine-tuned by the concerted action of both protein tyrosine kinases and protein tyrosine phosphatases (PTPs), is a key mechanism in tumorigenesis. Studies suggest potential role for PTP-PEST in regulation of p130(cas) in mitogen- and cell adhesion-induced signaling events (2).


Gene Aliases:

PTP-PEST, PTPG1, tcag7.1075


Genbank Number:


References:


1. Angers-Loustau, A. et al: Protein tyrosine phosphatase-PEST regulates focal adhesion disassembly, migration, and cytokinesis in fibroblasts. J. Cell Biol. 1999; 144: 1019-31.

2. Garton, A.J. et al: Identification of p130(cas) as a substrate for the cytosolic protein tyrosine phosphatase PTP-PEST. Mol. Cell Biol. 1996; 16(11):6408-18.


Specific Activity:

Sample Enzyme Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~66kDa



Product Datasheets



Safety Datasheet



There are no related publications available for this product.


RESEARCH AREAS

Cancer, Inflammation, Invasion/Metastasis, JAK/STAT Pathway, Metabolic Disorder, Phosphatases, WNT Signaling


RELATED PRODUCTS


  PTPN2 (TC-PTP), Active, P29-20G

  Phosphatase Assay Buffer II, P02-09

  PTPRM (PTP- mu) Protein, P58-35G


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