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PTPN11 (SHP2), Active

Recombinant full-length human PTPN11 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. P38-20G


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Catalog No. Pack Size Price (USD)
P38-20G-05 5 ug $226
P38-20G-10 10 ug $325
P38-20G-BULK BULK Contact Us  


Overview:

Mammalian PTPases can be subdivided into 1 of 2 broad categories: transmembrane receptor PTPases and intracellular PTPases. PTPN11 is one of the 2 closely related mammalian intracellular PTPases whose sequences encode 2 tandem SRC homology 2 (SH2) domains that are located at the amino-terminal side of a single PTPase catalytic domain (1). This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration (2)


Gene Aliases:

SHP2, CFC, NS1, BPTP3, PTP2C, PTP-1D, SH-PTP2, SH-PTP3, MGC14433


Genbank Number:


References:


1. Dechert, U. et al: Protein-tyrosine phosphatase SH-PTP2 (PTPN11) is localized to 12q24.1-24.3. Hum. Genet. 96: 609-615, 1995.

2. Ahmad, S. et al: A widely expressed human protein-tyrosine phosphatase containing src homology 2 domains. Proc. Nat. Acad. Sci. 90: 2197-2201, 1993


Specific Activity:

Sample Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability, and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

98 kDa



Product Datasheets



Safety Datasheet



RESEARCH AREAS

Cancer, Inflammation, Invasion/Metastasis, JAK/STAT Pathway, Metabolic Disorder, Phosphatases, WNT Signaling


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