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PTPN13 (FAP-1), Active

Recombinant human PTPN13 (2169-2485) was expressed in E.coli cells using a N-terminal GST tag.
Catalog No. P40-21G


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Catalog No. Pack Size Price (USD)
P40-21G-05 5 ug $226
P40-21G-10 10 ug $325
P40-21G-BULK BULK Contact Us  


Overview:

PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. PTPN13 is a large protein that possesses a PTP domain at C-terminus, and multiple noncatalytic domains, which include a domain with similarity to band 4.1 superfamily of cytoskeletal-associated proteins, a region consisting of five PDZ domains, and a leucine zipper motif (1). PTPN13 binds to a negative regulatory domain in Fas that inhibits Fas-induced apoptosis (2).


Gene Aliases:

PTP-BAS, PNP1, FAP-1, PTP1E, PTPL1, PTPLE, PTP-BL, DKFZp686J1497


Genbank Number:


References:


1. Saras, J. et al: Cloning and characterization of PTPL1, a protein tyrosine phosphatase with similarities to cytoskeletal-associated proteins. J. Biol. Chem. 269: 24082-24089, 1994.

2. Inazawa, J. et al: PTPN13, a Fas-associated protein tyrosine phosphatase, is located on the long arm of chromosome 4 at band q21.3. Genomics 31: 240-242, 1996.


Specific Activity:

Sample Enzyme Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~61 kDa



Product Datasheets



Safety Datasheet



There are no related publications available for this product.


RESEARCH AREAS

Cancer, Inflammation, Invasion/Metastasis, JAK/STAT Pathway, Metabolic Disorder, Phosphatases, WNT Signaling


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