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CDC25C, Active

Full-length recombinant human CDC25C was expressed in Sf9 insect cells using an N-terminal GST tag.
Catalog No. C04-20CG


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Catalog No. Pack Size Price (USD)
C04-20CG-05 5 ug $226
C04-20CG-10 10 ug $325
C04-20CG-BULK BULK Contact Us  


Overview:

CDC25C (also known as cell division cycle 25 homolog C) is a member of the CDC25 phosphatase family. CDC25C is highly conserved during evolution and it plays a key role in the regulation of cell division. CDC25C activates the partially purified p34 (cdc2)/cyclin B complex and directs the dephosphorylation of cyclin B-bound CDC2 and triggers entry into mitosis (1). CDC25C also suppresses p53-induced growth arrest. The regulation of CDC25B phosphorylation by p38 is a critical event for initiating the G2/M checkpoint after ultraviolet radiation (2).


Gene Aliases:

CDC25


Genbank Number:


References:


1. Gould, K. L. et.al: Complementation of the mitotic activator, p80(cdc25), by a human protein-tyrosine phosphatase. Science 250: 1573-1576, 1990.

2. Bulavin, D. V. et.al: Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase. Nature 411: 102-107, 2001.


Specific Activity:

Sample Enzyme Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~84 kDa



Product Datasheets



Safety Datasheet



There are no related publications available for this product.


RESEARCH AREAS

Cancer, Cell Cycle, Ser/Thr Kinases


RELATED PRODUCTS


  Anti-CDC25A, C04-63R

  CDC25A, Active, C04-20G

  CDC25B, Active, C04-20BG

  CDC7/DBF4, Active, C26-10G


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