PP2Cγ is a member of the PP2C family of Ser/Thr protein phosphatases which are known to be negative regulators of cell stress response pathways. PP2C gamma is found to be responsible for the dephosphorylation of Pre-mRNA splicing factors, which is important for the formation of functional spliceosome (1). PP2C gamma is highly expressed in testis, skeletal muscle, and heart (2). PP2C gamma also plays a main role in regulating cell cycle progression.
PP2C-GAMMA, PP2CG, PPM1G, PPP2CG, MGC1675, MGC2870
1. Murray, M. V. et.al: The type 2C Ser/Thr phosphatase PP2C-gamma is a pre-mRNA splicing factor. Genes Dev. 13: 87-97, 1999.
2. Travis, S. M. et.al: PP2C-gamma: a human protein phosphatase with a unique acidic domain. FEBS Lett. 412: 415-419, 1997.
Sample Enzyme Activity Plot. For specific information on a given lot, see related technical data sheet.
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Cancer, Cardiovascular Disease, Cell Cycle, ERK/MAPK Pathway, Metabolic Disorder, Phosphatases, Ser/Thr Kinases