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PP1A, Active

Recombinant full-length human PP1A was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. P13-20G


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Catalog No. Pack Size Price (USD)
P13-20G-05 5 ug $226
P13-20G-10 10 ug $325
P13-20G-BULK BULK Contact Us  


Overview:

PP1A is a serine/threonine specific protein phosphatase family which is involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. PP1A is one of the three catalytic subunits of protein phosphatase 1 (PP1) (1). PP1A functions as a suppressor of learning and memory and as a potential mediator of cognitive decline during aging (2).PP1A is also play a main role in splice site selection and is an important regulator of cardiac function.


Gene Aliases:

LAR


Genbank Number:


References:


1. Cohen, P.et.al: Protein phosphatases come of age. J. Biol. Chem. 264: 21435-21438, 1989.

2. Genoux, D. et.al: Protein phosphatase 1 is a molecular constraint on learning and memory. Nature 418: 970-975, 2002.


Specific Activity:

Sample Enzyme Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~62 kDa



Product Datasheets



Safety Datasheet



There are no related publications available for this product.


RESEARCH AREAS

Cancer, Cardiovascular Disease, Cell Cycle, ERK/MAPK Pathway, Metabolic Disorder, Phosphatases, Ser/Thr Kinases


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  PP2B Protein, P18-34G

  PP2B Substrate, P51-58


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