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PTPRA (LRP), Active

Recombinant human PTPRA (174-802) was expressed in E. coli cells using an N-terminal GST tag.
Catalog No. P48-21G


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Catalog No. Pack Size Price (USD)
P48-21G-05 5 ug $226
P48-21G-10 10 ug $325
P48-21G-BULK BULK Contact Us  


Overview:

PTPRA (also known as LRP) is a member of the protein tyrosine phosphatase family and contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains. PTPRA dephosphorylates SRC family kinases, potassium channels and NMDA receptors and exists as three alternatively spliced variants which encode two distinct isoforms (1). Absence of PTPRA compromises correct positioning of pyramidal neurons during development of mouse hippocampus (2).


Gene Aliases:

LRP, HLPR, PTPA, HEPTP, HPTPA, RPTPA, PTPRL2, HPTPalpha, R-PTP-alpha


Genbank Number:


References:


1. Matthews, R J. et al: Identification of an additional member of the protein-tyrosine-phosphatase family: evidence for alternative splicing in the tyrosine phosphatase domain. Proc. Nat. Acad. Sci. 87: 4444-4448, 1990.

2. Petrone, A. et al: Receptor protein tyrosine phosphatase alpha is essential for hippocampal neuronal migration and long-term potentiation. EMBO J. 2003 Aug 15;22(16):4121-31.


Specific Activity:

Sample Enzyme Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~96 kDa



Product Datasheets



Safety Datasheet



There are no related publications available for this product.


RESEARCH AREAS

Cancer, Invasion/Metastasis, Phosphatases


RELATED PRODUCTS


  PTPRM (PTP- mu) Protein, P58-35G

  PTPRE, Active, P52-21G


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