Recombinant 2019-nCoV PLpro/papain-like protease, part of a large replicase polyprotein 1ab (E1564-Y1882), was expressed in E. coli cells with a C-terminal His tag.
Catalog No. C19PL-G241H
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| C19PL-G241H-05 | 5 ug | $160 | |
| C19PL-G241H-10 | 10 ug | $226 | |
| C19PL-G241H-20 | 20 ug | $320 | |
| C19PL-G241H-50 | 50 ug | $450 | |
| C19PL-G241H-BULK | BULK | Contact Us |
Overview:
2019-nCoV papain-like protease (PLpro), also known as SARS-CoV-2 PLpro, is a virally encoded cysteine protease that acts on three cleavage sites of the viral polyprotein to release mature non-structural proteins (nsp) 1, 2 and 3, a process that is essential for viral replication. In addition, PLpro possesses deubiquitinating and deISGylating activities, thus negatively regulating the ubiquitin and ISG15-dependent host immune response during viral infection. PLpro also participates together with nsp4 in the assembly of virally-induced cytoplasmic double-membrane vesicles necessary for viral replication.
Gene Aliases:
SARS-CoV-2 PLpro
Genbank Number:
References:
1. Wu F. et al: A new coronavirus associated with human respiratory disease in China. Nature 579: 265-269, 2020
2. Báez-Santos Y. M. et al: The SARS-coronavirus papain-like protease: structure, function and inhibition by designed antiviral compounds. Antiviral Res. 115: 21-38, 2015
3. Lindner H. A. et al: The papain-like protease from the severe acute respiratory syndrome coronavirus is a deubiquitinating enzyme. J Virol. 79:15199-15208, 2005
Activity:
Sample Activity Plot. For specific information on a given lot, see related technical data sheet.
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Activity:
PLpro inhibition profile in the presence of various concentrations of PR-619, a broad spectrum and reversible DUB inhibitor.
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Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
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Storage, Stability, and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
38 kDa
There are no related publications available for this product.
Acute Respiratory Distress Syndrome , Angiogenesis, Cardiovascular Disease, Cell Cycle, Cellular Stress, COVID19, Gastrointestinal Diseases , Infectious Diseases , Inflammation, Lung Diseases , Neurobiology, severe acute respiratory syndrome coronavirus 2 , Virology
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