Home   >    Proteins   >   Protein Kinases

MRCK alpha, Active

Recombinant human MRCKalpha (1-473) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. C27-11G


Shop Online



Catalog No. Pack Size Price (USD)
C27-11G-05 5 ug $226
C27-11G-10 10 ug $325
C27-11G-BULK BULK Contact Us  


Overview:

Myotonic Dystrophy Kinase-Related Cdc42-Binding Kinase α (MRCKα) is a Cdc42/Rac/Rho interactive/binding serine/threonine kinase with multiple functional domains (1). MRCK are effectors of RhoA and Cdc42, respectively, for actin reorganization. MRCKα is a critical regulator of signal transduction pathways in eukaryotic cells that are known principally for their role in regulating the cytoskeleton, and they do so by recruiting a variety of downstream effector proteins (2).


Gene Aliases:

CDC42BPA, MRCK, PK428, FLJ23347, KIAA0451, DKFZp686L1738, DKFZp686P1738


Genbank Number:


References:


1. Ivan, T. et al: Genomic organization of human myotonic dystrophy kinase-related Cdc42-binding kinase α reveals multiple alternative splicing and functional diversity. Gene; 2003; 304:107-115.

2. Ivan, T. et al: Phosphorylation of a Novel Myosin Binding Subunit of Protein Phosphatase 1 Reveals a Conserved Mechanism in the Regulation of Actin Cytoskeleton. J. Biol. Chem., 2001: 276 (24): 21209-21216.


Specific Activity:

Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~73 kDa



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Angiogenesis, Cancer, Invasion/Metastasis, Ser/Thr Kinases


RELATED PRODUCTS


  Kinase Assay Buffer I, K01-09

  S6K Substrate, S05-58

  MRCK beta, Active, C28-11G

  DMPK, Active, D07-10G


SIGNALCHEM BIOTECH INC.


About

Terms of Service

Privacy Policy

Get the latest resources, updates and offers in your inbox