Overview:

High-temperature requirement factor A3 (HTRA3) is a member of the HTRA family of serine proteases that was initially identified in E. coli by two phenotypes of null mutants that were unable to grow at elevated temperatures. HTRA3 was discovered initially as a pregnancy-related serine protease (PRSP) identified by DDPCR (Differential Display Polymerase Chain Reaction) to be differentially expressed between implantation and interimplantation sites in the mouse uterus. A reduction of HTRA3 mRNA expression in ovarian cancer suggested that HTRA3 may act as a tumor suppressor.

Gene Aliases:

PRSP; TASP

Genbank Number:

NM_053044

References:

1. Strauch KL, et al: An Escherichia coli mutation preventing degradation of abnormal periplasmic proteins. Proc Natl Acad Sci U S A. 85(5):1576–1580. 1988.

2. Nie GY, et al. A novel serine protease of the mammalian HtrA family is up-regulated in mouse uterus coinciding with placentation. Mol Hum Reprod. 9(5):279–290. 2003.

3. Bowden MA, et al: High-temperature requirement factor A3 (Htra3): a novel serine protease and its potential role in ovarian function and ovarian