Recombinant human CAMK2gamma (c-terminal truncation) was expressed by baculovirus in Sf9 cells using an N-terminal GST tag.
Catalog No. C14-10G
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| C14-10G-05 | 5 ug | $226 | |
| C14-10G-10 | 10 ug | $325 | |
| C14-10G-BULK | BULK | Contact Us |
Overview:
CAMK2γ is a member of the CAMKII family which are ubiquitous serine/threonine protein kinases that have been implicated in diverse effects of hormones and neurotransmitters. CAMK2γ has six alternatively spliced variants that encode six different isoforms. Some of these variants have been identified in human tumors (1). Transgenic mice expressing a partially calcium-independent mutant form of CAMKG showed 1.5- to 2-fold increase in the thymus of these mice, at least in part due to an increase in the life span of double-positive thymocytes (2). There was an increase in the number of T cells in the secondary lymphoid organs that had acquired an antigen-dependent memory phenotype.
Gene Aliases:
CAMKG, CAMK, CAMK-II, MGC26678
Genbank Number:
References:
1. Tombes, R. M. et al: Identification of novel human tumor cell-specific CaMK-II variants. Biochim. Biophys. Acta 1355: 281-292, 1997.
2. Bui, J. D. et al: A role for CaMKII in T cell memory. Cell 100: 457-467, 2000.
Specific Activity:
Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
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Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
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Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
~60 kDa
A Thorne Curtis et al., Small-molecule inhibition of Wnt signaling through activation of casein kinase 1α Nature Chemical Biology November 2010 10.1038/nchembio.453
Caroccia Alessia et al., N-(Phenoxyalkyl)amides as MT(1) and MT(2) ligands: antioxidant properties and inhibition of Ca(2+)/CaM-dependent kinase II. Bioorganic & Medicinal Chemistry February 2013 10.1016/j.bmc.2012.12.017
Cipolletta E et al., Calmodulin-Dependent Kinase II Mediates Vascular Smooth Muscle Cell Proliferation and Is Potentiated by Extracellular Signal Regulated Kinase Endocrinology June 2010 10.1210/en.2009-1248
A. Witczak Carol et al., CaMKII regulates contraction- but not insulin-induced glucose uptake in mouse skeletal muscle. American Journal of Physiology - Endocrinology and Metabolism June 2010 10.1152/ajpendo.00659.2009
Illario Maddalena et al., Calcium-calmodulin-dependent kinase II (CaMKII) mediates insulin-stimulated proliferation and glucose uptake Cellular signalling January 2007 10.1016/j.cellsig.2009.01.022
C Bruno et al., The chemosensitizing agent lubeluzole binds calmodulin and inhibits Ca(2+)/calmodulin-dependent kinase II. European Journal of Medicinal Chemistry June 2016 10.1016/j.ejmech.2016.03.045
Monterrey Gomez et al., Characterization of a selective CaMKII peptide inhibitor European Journal of Medicinal Chemistry April 2013 10.1016/j.ejmech.2012.12.053
Cardiovascular Disease, ERK/MAPK Pathway, Neurobiology, PKA/PKC Pathway, Ser/Thr Kinases
CAMK2 alpha, Active, C11-10G
CAMKK2, Active, C18-10G
Kinase Assay Buffer I, K01-09
Kinase Dilution Buffer III, K23-09
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