ALK5 Inhibitor
Catalog No. T07-901
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| T07-901-05 | 5 mg | $110 | |
| T07-901-25 | 25 mg | $450 | |
| T07-901-BULK | BULK | Contact Us |
Overview:
Selective ALK5 inhibitor, IC50=59, 400 and 1400 nM for TGF-β RI, TGF-β RII and MLK-7K, respectively1. Inhibits Smad2 phosphorylation induced by TGF-β as well as fibronectin expression and MDA-MB-231 cell invasion2.
References:
1. JS Sawyer et al. J. Med. Chem. 2003 46:3953
2. SR Shiou et al. J. Biol. Chem. 2006 281:33971
3. ME Hardee et al. Cancer Res. 2012 72:4119
CAS Registry Number:
396129-53-6
Molecular Formula:
C17H12N4
Appearance:
Brown Powder
Molecular Weight:
272.31
Purity:
>98% (TLC); NMR (Conforms)
Solubilization:
May be dissolved in DMSO (25 mg/ml)
Aliases:
4-(3-Pyridin-2-yl-1H-pyrazol-4-yl)quinolone; HTS-466284
Storage and Stability:
Store desiccated as supplied at ambient temperature for up to 2 year. Store solutions at -20oC for up to 3 months.
Molecular Structure:
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There are no related publications available for this product.
AKT/PKB Pathway, Angiogenesis, Cancer, Cell Cycle, Cellular Stress, ERK/MAPK Pathway, Inflammation, JAK/STAT Pathway, JNK/SAPK Pathway, NfkB Pathway, Ser/Thr Kinases, WNT Signaling
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