Enzymes, Signaling Proteins, Extracellular Ligands, Signaling Reagents, Antibodies

Rapamycin

mTOR inhibitor
Catalog No. F17-901

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Catalog No.	Pack Size	Price (USD)
F17-901-10	10 mg	$75
F17-901-50	240 mg	$240
F17-901-BULK	BULK	Contact Us

Overview:

Potent immunosuppressant. The rapamycin-FKBP12 complex binds to and inhibits mTOR (1). Inhibits IL-2-induced activation of p70 S6 kinase (2). Extends lifespan of mice (3). Induces autophagy in a variety of cell lines (4).

References:

1. S Huang et al. Cancer Biol. Ther. 2003 2:222

2. CJ Kuo et al. Nature 1992 358:70

3. DE Harrison et al. Nature 2009 460:392

4. A Flemming et al. Nat. Chem. Biol. 2011 7:9

CAS Registry Number:

53123-88-9

Molecular Formula:

C₅₁H₇₉NO₁₃

Appearance:

White crystalline powder

Melting Point:

N/A

Molecular Weight:

914.2

Purity:

>98% (TLC: 10% CH3OH in CH2Cl2; Rf=0.51); NMR (Conforms)