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MATK (CTK), Active

Full-length recombinant human MATK (CTK) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. M49-10G


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Catalog No. Pack Size Price (USD)
M49-10G-05 5 ug $226
M49-10G-10 10 ug $325
M49-10G-BULK BULK Contact Us  


Overview:

MATK belongs to tyrosine protein kinase family, CSK subfamily. It inactivates Src family kinase activity by specifically phosphorylating their C-terminal regulatory tyrosine residue and may plays a significant role in the signal transduction of hematopoietic cells (1). MATK binds to the phosphorylated Tyr568/570 sites on c-KIT to which FYN binds and leads to the down-regulation of FYN (2). MATK has been shown to be involved in signaling in some cases of breast cancer.


Gene Aliases:

CHK; CTK; HHYLTK; HYL; HYLTK; LSK


Genbank Number:


References:


1. Hirao A. et.al: Translocation of the Csk homologous kinase (Chk/Hyl) controls activity of CD36-anchored Lyn tyrosine kinase in thrombin-stimulated platelets. EMBO J. 16:2342-2351(1997).

2. Price D.J. et.al: Direct association of Csk homologous kinase (CHK) with the diphosphorylated site Tyr568/570 of the activated c-KIT in megakaryocytes. J. Biol. Chem. 272:5915-5920(1997).


Specific Activity:

Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~83 kDa



There are no related publications available for this product.


RESEARCH AREAS

Cancer, Cytoplasmic Tyrosine Kinases


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