Home    >   Phosphatase Inhibitors

Okadaic acid, free acid

PP2A and PP1 inhibitor
Catalog No. P16-902


For enquiry on all Phosphatase Inhibitors email us at orders@signalchem.com


Catalog No. Pack Size Price (USD)
P16-902-100 100 ug $259
P16-902-20 20 ug $72
P16-902-BULK BULK Contact Us  


Overview:

A naturally occurring polyether marine toxin. Potent and selective inhibitor of protein phosphatases inhibiting PP2A completely at 1nM and PP1 at higher concentrations, while PP2C is not inhibited. It is an extremely useful tool for studying cellular protein phosphorylation (2). Induces apoptosis in a variety of cell types (3). Activates atypical protein kinase isotypes and induces insulin-like effects in adipocytes (4).

References:


1. P Cohen et al. Trends Biochem. Sci.1990 15:98.

2. DG Hardie et al. Methods Ezymol.1991 201:469.

3. TJ Haneji et al. Int. J. Oncol. 2013 42:1904.

4. ML Standaert et al. J. Biol. Chem. 1999 274:14074.


CAS Registry Number:

78111-17-8


Molecular Formula:

C44H68O13


Appearance:

White lyophilized solid


Melting Point:

N/A


Molecular Weight:

805


Purity:

>98% (TLC)


Solubilization:

May be dissolved in DMSO (40 mg/ml); or Ethanol (5 mg/ml)


Aliases:

None


Storage and Stability:

Store desiccated as supplied at -20oC for up to 2 years. Store solutions at -20o for up to 1 month.


Molecular Structure:



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Cancer, Cardiovascular Disease, Cell Cycle, ERK/MAPK Pathway, Metabolic Disorder, Phosphatases, Ser/Thr Kinases



SIGNALCHEM BIOTECH INC.


About

Terms of Service

Privacy Policy

Get the latest resources, updates and offers in your inbox