Recombinant Human TGF Beta-3 (TGFB3) was expressed in E. coli cells.
Catalog No. T833-40N
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| T833-40N-10 | 10 ug | $237 | |
| T833-40N-BULK | BULK | Contact Us |
Overview:
Transforming Growth Factor Beta-3 is a disulfide-linked homodimeric, non-glycosylated, protein that is one of the isoforms of the highly pleiotropic cytokines that are secreted by all cell types. TGF Beta-1, TGF Beta-2, and TGF Beta-3 use the same receptor and act as cellular switches that regulate cell growth, proliferation, differentiation, motility, extracellular matrix synthesis, and immune function regulation. Defects of this gene can cause arrhythmogenic right ventricular dysplasia 1 and rienhoff syndrome. TGFB3 first interacts with the accessory receptor betaglycan (TGF Beta-R3) and a type II serine/threonine kinase receptor (TGF Beta-R2). The receptor then activates a type I serine/threonine kinase receptor such as ALK-1 or TGF Beta-R1 (ALK-5) through phosphorylation, and the activated type I receptor activates Smad proteins to regulate transcription.
Genbank Number:
Storage, Stability and Shipping:
This cytokine can be stored in working aliquots at 2o - 8oC for two weeks. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Endotoxin Level:
<1.0 EU/μg of recombinant protein as determined by the LAL method
Molecular Weight:
13.0 kDa
Sample Cell Assay Data:
The ED50 is 0.01-0.04 ng/mL as determined by its ability to inhibit IL-4 dependent proliferation of HT-2 mouse cells.
Purity:
Recombinant Human TGF Beta-3 (TGFB3) resolved on a 15% SDS-PAGE gel under reducing conditions and stained with Coomassie Brilliant Blue G-250.
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