SIRT2 Inhibitor
Catalog No. S36-904
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| S36-904-5 | 5 mg | $85 | |
| S36-904-25 | 25 mg | $330 | |
| S36-904-BULK | BULK | Contact Us |
Overview:
A selective Sirt2 inhibitor (IC50=15.5 μM) which does not inhibit Sirt1 or Sirt31. It down-regulates cholesterol biosynthesis genes in primary striatal neurons1. Displays neuroprotective effects in Huntington’s disease mouse models including improved motor function, extended survival and reduced brain atrophy all of which were associated with reduced aggregated mutant huntingtin2.
References:
1. DM Taylor et al. ACS Chem. Biol. 2011 6:540
2. V Chopra et al. Cell Rep. 2012 2:1492
CAS Registry Number:
420831-40-9
Molecular Formula:
C19H21BrN2O3S
Appearance:
White powder
Melting Point:
148-151oC
Molecular Weight:
437.4
Purity:
98% (TLC)
Solubilization:
May be dissolved in DMSO (50 mg/ml); or ethanol (8 mg/ml, warm).
Aliases:
N-(3-Bromophenyl)-3-[(hexahydro-1H-azepin-1-yl)sulfonyl]benzamide
Storage and Stability:
Store desiccated as supplied at ambient temperature for up to 3 years. Store solutions at -20oC for up to 3 months.
Molecular Structure:
|
There are no related publications available for this product.
Cancer, Cell Cycle, Inflammation
STAY CONNECTED
Fax: 1-604-232-4601
Toll Free: 1-866-954-6273
info@signalchem.com