KDM2/7 Demethylase Inhibitor
Catalog No. K421-904B
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| K421-904B-50 | 50 mg | $60 | |
| K421-904B-250 | 250 mg | $135 | |
| K421-904B-BULK | BULK | Contact Us |
Overview:
A selective inhibitor of the KDM2/7 JmjC subfamily of histone demethylases. IC50=1.5, 0.55 and 2.1 uM for KDM2A, PHF8 and KDM7A respectively. Highly selective over other subfamily members (KDM3, KDM4, KDM5 and KDM6) as well as other 2-oxoglutarate oxygenases (FIH, PHD2 and BBOX1), IC50>100 uM1.
References:
1. NR Rose et al. J. Med. Chem. 2012 55:6639
CAS Registry Number:
1596-84-5
Molecular Formula:
C6H12N2O3
Appearance:
White powder
Melting Point:
158-162oC
Molecular Weight:
160.2
Purity:
98%
Solubilization:
May be dissolved in DMSO (50 mg/ml); or Water (20 mg/ml, warm)
Aliases:
1-(2,2-Dimethylhydrazide)butanedioic acid
Storage and Stability:
Store desiccated as supplied at ambient temperature for up to 3 years. Store solutions at -20oC for up to 3 months.
Molecular Structure:
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