Overview:

Calmodulin 1 is a member of calcium-modulated proteins which is present in the cytosol and on membranes facing the cytosol and has a high affinity for calcium. Calmodulin 1 has 4 calcium-binding domains and plays a role in cell growth, cell cycle, signal transduction and the synthesis and release of neurotransmitters. Calmodulin can bind to the epidermal growth factor receptor at its cytosolic juxtamembrane region and this inhibits its tyrosine kinase activity (1). A number of other proteins including HSP70 have been shown to interact with Calmodulin 1 in a cell-phase-specific manner (2).

Gene Aliases:

CALM1; CALML2; CAMI; DD132; PHKD

Genbank Number:

NM_006888

References:

1. Li, H. et al: Endogenous calmodulin interacts with the epidermal growth factor receptor in living cells. FEBS Lett. 2004 Feb 13;559(1-3):175-80.

2. Huang, M. et al: The association of CaM and Hsp70 regulates S-phase arrest and apoptosis in a spatially and temporally dependent manner in human cells. Cell Stress Chaperones. 2009 Jul;14(4):343-53.