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PARK7 (DJ-1) Protein

Recombinant human PARK7 (DJ-1) (19-end) was expressed in E. coli cells using an N-terminal His tag.
Catalog No. P219-31H


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Catalog No. Pack Size Price (USD)
P219-31H-20 20 ug $215
P219-31H-50 50 ug $435
P219-31H-BULK BULK Contact Us  


Overview:

PARK7 or parkinson protein 7 belongs to the peptidase C56 family of proteins which acts as a positive regulator of androgen receptor-dependent transcription. PARK7 also functions as a redox-sensitive chaperone, as a sensor for oxidative stress, and it apparently protects neurons against oxidative stress and cell death. PARK7 mutations that impair transcriptional co-activator function can render dopaminergic neurons vulnerable to apoptosis and may contribute to the pathogenesis of Parkinson disease (1). PARK7 is an atypical peroxiredoxin-like peroxidase that scavenges hydrogen peroxide through oxidation of cys106 (2).


Gene Aliases:

PARK7; DJ-1; DJ1


Genbank Number:


References:


1. Xu, J.et.al: The Parkinson's disease-associated DJ-1 protein is a transcriptional co-activator that protects against neuronal apoptosis. Hum. Molec. Genet. 14: 1231-1241, 2005.

2. Andres-Mateos.et.al: DJ-1 gene deletion reveals that DJ-1 is an atypical peroxiredoxin-like peroxidase. Proc. Nat. Acad. Sci. 104: 14807-14812, 2007.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~22 kDa



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Apoptosis/Autophagy, Cancer, Cell Cycle, Neurobiology


RELATED PRODUCTS


  Parkin Protein, P215-30G


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