Overview:

The severe acute respiratory syndrome related novel coronavirus (SARS-CoV) has caused the 2002-2003 SARS epidemic that broke out in southern China, which spread to other regions of Asia, Europe and North America (1). The spike glycoprotein (S) of coronavirus belongs to the type I transmembrane protein containing two subunits, S1 and S2 (2), which is also known to be the key component to bind with host cells through the interaction with angiotensin-converting enzyme 2 (ACE2). SARS-CoV can specifically recognize ACE2 through its receptor binding domain (RBD) of S1 to initiate viral infection in humans (3).

Gene Aliases:

SARS coronavirus S1, coronavirus S2, coronavirus spike, cov spike, ncov S1, ncov S2, ncov RBD, Spike RBD, RBD.

Genbank Number:

AY278554

References:

1. Li F, et al: Receptor recognition and cross-species infections of SARS coronavirus. Antiviral Research. 2013, 100 (1): 246-254.

2. Xiao X, et al: The SARS-CoV S glycoprotein. Cell Mol Life Sci. 2004, 61 (19-20): 2428-30.

3. Wan Y, et al: Receptor Recognition by the novel Coronavirus from Wuhan: An analysis based on decade-long structural studies of SARS Coronavirus. Journal of virology. 2020: 94.