Recombinant full-length human AURORA B was expressed by baculovirus in Sf9 insect cells using a N-terminal GST tag.
Catalog No. A31-10G
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| A31-10G-05 | 5 ug | $226 | |
| A31-10G-10 | 10 ug | $325 | |
| A31-10G-BULK | BULK | Contact Us |
Overview:
AURORA B is a member of the Aurora kinase family that associates with microtubules during chromosome movement and segregation. AURORA B localizes to the microtubules near kinetochores, specifically to the specialized microtubules called K-fibers (1). AURORA B inhibits the microtubule depolymerizing activity of mitotic centromere-associated kinesin (MCAK) by phosphorylating MCAK on Ser92 (2). This phosphorylation also regulates MCAK translocalization from kinetochores to the centromere. AURORA B has been identified as a target for the development of new anticancer agents since inhibition of AURORA B gives rise to the more pronounced antiproliferative phenotype.
Gene Aliases:
AURKB, AIK2; AIM1; ARK2; AurB; IPL1; AIM-1; STK12
Genbank Number:
References:
1. Shannon, K B. et al: Chromosome dynamics: new light on Aurora B kinase function. Curr Biol. 2002 Jul 9;12(13):R458-60.
2. Andrews, P. D. et al: Aurora B regulates MCAK at the mitotic centromere. Dev. Cell 6: 253-268, 2004.
Specific Activity:
Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
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Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
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Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
~68 kDa
A Stützer et al., Modulations of DNA Contacts by Linker Histones and Post-translational Modifications Determine the Mobility and Modifiability of Nucleosomal H3 Tails. Molecular Cell January 2016 10.1016/j.molcel.2015.12.015
Liokatis Stamatios et al., Phosphorylation of histone H3 Ser10 establishes a hierarchy for subsequent intramolecular modification events Nature Structural and Molecular Biology July 2012 10.1038/nsmb.2310
Han Areum et al., Methylation-mediated control of aurora kinase B and Haspin with epigenetically modified histone H3 N-terminal peptides Bioorganic & Medicinal Chemistry April 2011 10.1016/j.bmc.2011.02.011
Mandala Ranadip et al., pERK 1/2 inhibit Caspase-8 induced apoptosis in cancer cells by phosphorylating it in a cell cycle specific manner Molecular Oncology March 2013 10.1016/j.molonc.2013.11.003
Kassardjian Ari et al., The Transcription Factor YY1 Is a Novel Substrate for Aurora B Kinase at G2/M Transition of the Cell Cycle PLoS One November 2012 10.1371/journal.pone.0050645
Z Xingyu et al., Quercetin suppresses lung cancer growth by targeting Aurora B kinase. Cancer Med. November 2016 10.1002/cam4.891
et al., Microwave synthesis of new 3-(3-aminopropyl)-5-arylidene- 2-thioxo-1,3-thiazolidine-4-ones as potential Ser/Thr protein kinase inhibitors Medicinal Chemistry Research
December 2016 10.1007/s00044-016-1719-3
et al., Discovery of simplified benzazole fragments derived from the marine benzosceptrin B as necroptosis inhibitors involving the receptor interacting protein Kinase-1 European Journal of Medicinal Chemistry September 2020
et al., Cyanidioschyzon merolae aurora kinase phosphorylates evolutionarily conserved sites on its target to regulate mitochondrial division Communications Biology December 2019
et al., Biological Evaluation of Arylsemicarbazone Derivatives as Potential Anticancer Agents Pharmaceuticals November 2019
et al., Synthesis and anticancer activity of novel bisindolylhydroxymaleimide derivatives with potent GSK-3 kinase inhibition. Bioorganic & medicinal chemistry February 2019
Cancer, Cell Cycle, Ser/Thr Kinases
AURORA A, Active, A28-10G
AURORA C, Active, A33-10G
LKB1(STK11) Protein, L15-30G
AURORA B, Active, A31-10H
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