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RSK1, Active

Recombinant full-length human RSK1 was expressed by baculovirus in Sf9 insect cells using a N-terminal GST tag.
Catalog No. R15-10G


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Catalog No. Pack Size Price (USD)
R15-10G-05 5 ug $226
R15-10G-10 10 ug $325
R15-10G-BULK BULK Contact Us  


Overview:

RSK1 is a member of the RSK (ribosomal S6 kinase) family that are growth factor-regulated serine/threonine kinases. RSK1 contains 2 nonidentical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. RSK1 encodes a predicted 735-amino acid protein containing 2 distinct consensus ATP-binding site sequences. RSK1 transcript is present in lymphocytes, skeletal muscle, liver, and adipose tissue (1). RSKs are implicated in the activation of the mitogen-activated kinase (MAPK) cascade and the stimulation of cell proliferation and differentiation (2).


Gene Aliases:

RPS6KA1; HU-1; MAPKAPK1A; S6K-alpha 1


Genbank Number:


References:


1. Moller, D E. et al: Human rsk isoforms: cloning and characterization of tissue-specific expression. Am. J. Physiol. 266: C351-C359, 1994.

2. Gross, S D. et al: Induction of metaphase arrest in cleaving Xenopus embryos by the protein kinase p90(Rsk). Science 286: 1365-1367, 1999.


Specific Activity:

Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~108 kDa



Product Datasheets



RESEARCH AREAS

Apoptosis/Autophagy, Cancer, Cardiovascular Disease, ERK/MAPK Pathway, Inflammation, Neurobiology, NfkB Pathway, Ser/Thr Kinases


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  S6K Substrate, S05-58


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