Fyn A (Fyn isoform A) is a member of the SRC tyrosine kinase oncogene family showing high homology to YES1, FGR and SRC. Fyn has been shown to phosphorylate Dab1, an intracellular adaptor protein that interacts with amyloid precursor protein (APP) and apoE receptor 2 (apoEr2) (1). The interaction of Fyn and Dab1 regulates the phosphorylation, trafficking, and processing of APP and apoEr2. Fyn expression has been shown to be significantly increased in Chronic Myelogenous Leukemia (CML) (2). Knockdown of Fyn with shRNA slows leukemia cell growth, inhibits clonogenicity, and leads to increased sensitivity to imatinib.
SLK, SYN, MGC45350
1. Hoe, H S. et al: Fyn modulation of Dab1 effects on amyloid precursor protein and ApoE receptor 2 processing. J. Biol. Chem. 2008 Mar 7;283(10):6288-99.
2. Ban, K. et al: BCR-ABL1 mediates up-regulation of Fyn in chronic myelogenous leukemia. Blood, 2008 Mar 1;111(5):2904-8.
Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Ruilong L et al., Tyrosine phosphorylation activates 6-phosphogluconate dehydrogenase and promotes tumor growth and radiation resistance Nature Communications March 2019 10.1038/s41467-019-08921-8
A Binolfi et al., Intracellular repair of oxidation-damaged [alpha]-synuclein fails to target C-terminal modification sites Nature Communications January 2016 10.1038/ncomms10251
Y Yamazaki et al., Nicotine-induced neuroplasticity counteracts the effect of schizophrenia-linked neuregulin 1 signaling on NMDAR function in the rat hippocampus Neuropharmacology October 2016 10.1016/j.neuropharm.2016.10.021
Y Yamazaki et al., Nicotine-induced neuroplasticity counteracts the effect of schizophrenia-linked neuregulin 1 signaling on NMDAR function in the rat hippocampus. Neuropharmacology October 2016 10.1016/j.neuropharm.2016.10.021
Cancer, Cardiovascular Disease, Cytoplasmic Tyrosine Kinases, ERK/MAPK Pathway, Inflammation, Invasion/Metastasis, Neurobiology