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Recombinant full length human SHIP1 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. P08-20G
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
P08-20G-05 | 5 ug | $226 | |
P08-20G-10 | 10 ug | $325 | |
P08-20G-BULK | BULK | Contact Us |
Overview:
The SH2-containing inositol-5′-phosphatase, SHIP or SHIP1, is a hematopoietic-specific phosphatidylinositide phosphatase. It is recruited to the plasma membrane after extracellular stimulation and hydrolyzes the phosphatidylinositol-3-kinase-generated second messen-ger PI-3,4,5-P3 to PI-3,4-P2, downregulating PI-3,4,5-P3-mediated signaling and represses the proliferation, differentiation, survival, activation, and migration of hematopoietic cells. It has been shown that SHIP1 may act as a tumor suppressor during leukemogenesis and lymphomagenesis.
Gene Aliases:
INPP5D, SHIP, hp51CN, SIP-145, MGC142140, MGC142142
Genbank Number:
References:
1. Hamilton MJ, et al: Role of SHIP in cancer. Exp Hematol. 39(1):2-13, 2011.
2. Kavanaugh WM, et al: Multiple forms of an inositol polyphosphate 5-phosphatase form signaling complexes with Shc and Grb2. Current Biology. 6:438–445, 1996.
Specific Activity:
Sample Enzyme Activity Plot. For specific information on a given lot, see related technical data sheet.
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability, and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
144~160 kDa
R Stenton Grant et al., Characterization of AQX-1125, a small-molecule SHIP1 activator British Journal of Pharmacology March 2013 10.1111/bph.12039
et al., Loss of function of DOCK4 in myelodysplastic syndromes stem cells is restored by inhibitors of DOCK4 signaling networks Clinical cancer research : an official journal of the American Association for Cancer Research March 2020
AKT/PKB Pathway, Apoptosis/Autophagy, Cancer, Inflammation, Lipid Kinases
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