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Anti-UBA2 (SAE2)

Rabbit Polyclonal Antibody
Catalog No. U202-63R


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Catalog No. Pack Size Price (USD)
U202-63R-100 100 ug $325
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Overview:

UBA2 (SAE2) or ubiquitin-like modifier activating enzyme 2 forms a heterodimer that functions as a SUMO-activating enzyme for the sumoylation of proteins. The posttranslational modification of proteins by the addition of the small protein SUMO or sumoylation, regulates protein structure and intracellular localization (1). UBA2 functions in SUMO1 activation in a manner analogous to the single E1 ubiquitin-activating enzymes (2). The inactivation of UBA2 may be a therapeutic strategy in MYC-driven cancers.

References:


1. Okuma, T. et.al: In vitro SUMO-1 modification requires two enzymatic steps, E1 and E2. Biochem. Biophys. Res. Commun. 254: 693-698, 1999.

2. Desterro, J. et. al: Identification of the enzyme required for activation of the small ubiquitin-like protein SUMO-1. J. Biol. Chem. 274: 10618-10624, 1999.


Specificity:

Recognizes the UBA2 (SAE2) protein


Cross Reactivity:

Human


Host / Isotype / Clone#:

Rabbit, IgG


Immunogen:

UBA2 antibody was raised against an 18 amino acid synthetic peptide near the carboxy terminus of human UBA2


Purification:

Affinity chromatography


Stability:

Store at 4oC (add 0.1% NaN3) for several months, and at -20oC for longer periods. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Sample Data:

Western blot analysis of UBA2 in 293 cell lysate with UBA2 antibody at 0.25 ug/ml in (A) the absence and (B) the presence of blocking peptide.


Sample Data:

Immunocytochemistry of UBA2 in 293 cells with UBA2 antibody at 4 ug/ml.



Product Datasheets



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RESEARCH AREAS

Cancer, Cell Cycle, Cytoplasmic Tyrosine Kinases, Neurobiology



SIGNALCHEM BIOTECH INC.


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