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CSK, Active

Recombinant full-length tag-free human CSK was expressed by baculovirus in Sf9 insect cells.
Catalog No. C63-10U


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Catalog No. Pack Size Price (USD)
C63-10U-05 5 ug $226
C63-10U-10 10 ug $325
C63-10U-BULK BULK Contact Us  


Overview:

CSK is a cytoplasmic tyrosine kinase that has been shown to downregulate the tyrosine kinase activity of the c-src through tyrosine phosphorylation of the c-src carboxy terminus (1). A yeast 2-hybrid system has been used to identify proteins associated with CSK. The Src homology-3 (SH3) domain of CSK associates with a proline-rich region of PEP, a protein-tyrosine phosphatase expressed in hemopoietic cells (2). This association is highly specific and it is speculated that PEP may be an effector and/or regulator of CSK in T cells and other hemopoietic cells.


Gene Aliases:

MGC117393


Genbank Number:


References:


1. Partanen, J. et al: Cyl encodes a putative cytoplasmic tyrosine kinase lacking the conserved tyrosine autophosphorylation site (Y416-src). Oncogene 6: 2013-2018, 1991.

2. Cloutier, J.-F. et al: Association of inhibitory tyrosine protein kinase p50(csk) with protein tyrosine phosphatase PEP in T cells and other hemopoietic cells. EMBO J. 15: 4909-4918, 1996.


Specific Activity:

Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~52 kDa



Product Datasheets



RESEARCH AREAS

Cancer, Cytoplasmic Tyrosine Kinases, Inflammation


RELATED PRODUCTS


  SRC, Active, S19-10G

  CSK, Active, C63-10G

  Kinase Assay Buffer II, K02-09

  Poly (4:1 Glu, Tyr) Peptide, P61-58


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