BTK inhibitor
Catalog No. B10-901
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| B10-901-05 | 5 mg | $105 | |
| B10-901-25 | 25 mg | $420 | |
| B10-901-BULK | BULK | Contact Us |
Overview:
Potent and selective inhibitor of Bruton's tyrosine kinase (BTK). Inhibits recombinant BTK with an IC50 = 2.5 uM (1) and has no activity at other protein kinases (including JAK1, JAK3, HCK, EGFR kinase and insulin receptor kinase) at concentrations up to 300 uM (2).
References:
1. S Mahajan et al. J. Biol. Chem. 1999 274:9587
2. A Vassilev et al. J. Biol. Chem. 1999 274:1646
CAS Registry Number:
62004-35-7
Molecular Formula:
C11H8Br2N2O2
Appearance:
Yellow powder
Melting Point:
145-146oC
Molecular Weight:
360.0
Purity:
98% (TLC: 2:8 CH3OH:CH2Cl2; Rf=0.53); NMR (Conforms)
Solubilization:
DMSO (10 mg/ml) and ethanol (15 mg/ml)
Aliases:
2-Cyano-N-(2,5-dibromophenyl)-3-hydroxy-2-butenamide
Storage and Stability:
Store desiccated as supplied at -20oC for up to 2 years. Store solutions at -20oC for up to 3 months.
Molecular Structure:
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There are no related publications available for this product.
Cancer, Cytoplasmic Tyrosine Kinases, Inflammation, NfkB Pathway
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