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PKC iota, Active

Recombinant full-length human PKCiota was expressed by baculovirus in Sf9 insect cells using a N-terminal GST tag.
Catalog No. P68-10G


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Catalog No. Pack Size Price (USD)
P68-10G-05 5 ug $160
P68-10G-10 10 ug $226
P68-10G-BULK BULK Contact Us  


Overview:

PKCι is a member of the protein kinase C family of serine-threonine kinases. The amino acid sequence of PKCι showed greatest homology to PKCzeta, with 72% identity overall rising to 84% in the catalytic domain. Protein kinase C iota (PKCι) has been implicated in Ras signaling and is a critical downstream effector of oncogenic Ras in the colonic epithelium. Transgenic mice expressing constitutively active PKCι in the colon are highly susceptible to carcinogen-induced colon carcinogenesis (1).


Gene Aliases:

PRKCI; DXS1179E; MGC26534; nPKC-iota


Genbank Number:


References:


1. Murray, N R. et al: Protein kinase C iota is required for Ras transformation and colon carcinogenesis in vivo. J Cell Biol. 2004 Mar 15;164(6):797-802.


Specific Activity:

Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~98 kDa



Product Datasheets



RESEARCH AREAS

Apoptosis/Autophagy, Cardiovascular Disease, ERK/MAPK Pathway, Neurobiology, NfkB Pathway, PKA/PKC Pathway, Ser/Thr Kinases


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