Overview:

YSK4 (MAP3K19, RCK) belongs to STE Ser/Thr protein kinase family and STE20 subfamily. The YSK4 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, and rat (1). The important paralog is MAP3K1 gene. The RCK ligand-binding domains form an octameric gating ring (2) in the large-conductance Ca2+-activated K+ channels (3). The YSK4 kinase function has not been made clearly yet.

Gene Aliases:

RCK; MAP3K19

Genbank Number:

NM_025052

References:

1. Hillier LW, et al: Generation and annotation of the DNA sequences of human chromosomes 2 and 4. Nature, 2005 Apr 7.

2. Ye S. et al: Crystal Structures of a Ligand-free MthK Gating Ring: Insights into the Ligand Gating Mechanism of K(+) Channels. Cell (2006).

3. Santarelli, L.C. et al: Three methionine residues located within the regulator of conductance for K+ (RCK) domains confer oxidative sensitivity to large-conductance Ca2+-activated K+ channels. Physiol. (Lond.) (2006).