Overview:

CLK/STY is a member of the CDC2-like (or LAMMER) family of dual specificity protein kinases. The phosphorylated serine/arginine-rich (SR) proteins involves in the pre-mRNA processing and releasing through nucleus into nucleoplasm. CLK/STY, which could phosphorylates the specific SR proteins (1), such as ASF/SF2, may directly regulates the activity and compartmentalization of SR splicing factors (2).

Gene Aliases:

CLK, STY, CLK/STY

Genbank Number:

NM_004071

References:

1. Prasad J et al: Regulation and substrate specificity of the SR protein kinase Clk/Sty. Mol Cell Biol. 2003 Jun; 23(12): 4139-49.

2. Colwill, K. et al: SRPK1 and Clk/Sty protein kinases show distinct substrate specificities for serine/arginine-rich splicing factors. J. Biol. Chem. 271: 24569-24575, 1996.