Recombinant full-length human AURORA C was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. A33-10G
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| A33-10G-05 | 5 ug | $226 | |
| A33-10G-10 | 10 ug | $325 | |
| A33-10G-BULK | BULK | Contact Us |
Overview:
Aurora C is a member of mitotic serine/threonine kinases that regulate centrosome maturation, chromosome segregation, and cytokinesis. Aurora C has been shown to contribute to oncogenic transformation and is frequently overexpressed and amplified in many human tumors (1). Aurora C overexpression has been correlated with centrosome amplification, which can be a driving cause of genomic instability in tumor cells. Aurora C is an important regulator of both genomic integrity and cell cycle progression in cancer cells and is an attractive target for anticancer drug development (2).
Gene Aliases:
AURKC, AIE2, AIK3, AurC, STK13, aurora-C
Genbank Number:
References:
1. Steven, L. et al: Targeting Aurora-2 Kinase in Cancer. Molecular Cancer Therapeutics. 2003;2: 589-595
2. Shingo, T. et al: The centrosomal protein Lats2 is a phosphorylation target of Aurora-A kinase. Genes to Cells. 2004; 9: 383-397
Specific Activity:
Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
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Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
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Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
~61 kDa
Kassardjian Ari et al., The Transcription Factor YY1 Is a Novel Substrate for Aurora B Kinase at G2/M Transition of the Cell Cycle PLoS One November 2012 10.1371/journal.pone.0050645
et al., Acetylshikonin suppressed growth of colorectal tumour tissue and cells by inhibiting the intracellular kinase, T?lymphokine?activated killer cell?originated protein kinase. British Journal of Pharmacology April 2020
Cancer, Cell Cycle, Ser/Thr Kinases
AURORA A, Active, A28-10G
AURORA A, Active, A28-18G
PLK1, Active, P41-10H
Kinase Dilution Buffer III, K23-09
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