Recombinant full-length human MAST2 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. M69-11G
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| M69-11G-05 | 5 ug | $259 | |
| M69-11G-10 | 10 ug | $380 | |
| M69-11G-BULK | BULK | Contact Us |
Overview:
Microtubule associated serine/threonine kinase 2 (MAST2) belongs to the AGC Ser/Thr protein kinase family. MAST2 translocations was identified in invasive breast carcinoma, which occurs during the transition to ductal carcinoma in situ (DCIS) and/or invasive carcinoma. By interacting with Phosphatase and tensin homologue (PTEN) mediated by its PDZ domain, MAST2 plays a key negative role in regulating survival pathways in neuronal cells. The two proteins interact via the PDZ domain of MAST2.
Gene Aliases:
MAST205, MTSSK, KIAA0807
Genbank Number:
References:
1. Clay MR, et al. MAST2 and NOTCH1 translocations in breast carcinoma and associated pre-invasive lesions. Hum Pathol. 44:2837-44, 2013
2. Delhommel F, et al. Deciphering the unconventional peptide binding to the PDZ domain of MAST2. Biochem J. 469:159-68, 2015
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
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Storage, Stability, and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
~140 kDa
Specific Activity:
Sample Activity Plot. For specific information on a given lot, see related technical data sheet.
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There are no related publications available for this product.
Cancer, Ser/Thr Kinases, WNT Signaling
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