Overview:

ERK3 (MAPK6) or mitogen-activated protein kinase 6 is a member of the Ser/Thr protein kinase family, and is most closely related to mitogen-activated protein kinases (MAP kinases) which also known as extracellular signal-regulated kinases (ERKs) that are activated through protein phosphorylation cascades and act as integration points for multiple biochemical signals and tyrosine phosphorylated in response to insulin and NGF (1). ERK3 is highly expressed in various human tissues, most abundantly in skeletal muscle (2).

Gene Aliases:

ERK3; MAPK6; HsT17250; p97MAPK; PRKM6

Genbank Number:

NM_002748

References:

1. Boulton, T. G.et.al: ERKs: a family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF. Cell 65: 663-675, 1991.

2. Meloche, S. et.al: Primary structure, expression and chromosomal locus of a human homolog of rat ERK3. Oncogene 13: 1575-1579, 1996.